Auteur(s): C. U. M. Smith
Genre: Studie, Wetenschap
Uitgave: paperback, Engelstalig
Aantal bladzijden: 522
Uitgever: John Wiley & Sons, Chichester/New York
1e Druk, Jaartal: 1996
Afmetingen: 244 x 188 x 31 mm
Gewicht: 1002 g + 130 g (verpakking) = 1132 g
Elements of molecular neurobiology – C. U. M. Smith
This thoroughly updated and revised new edition of C.U.M. Smith’s widely read 1989 book presents a molecular account of the structure, development and functioning of the brain. Our understanding of molecular neurobiology has undergone dramatic development in recent years. The molecular approach has elucidated the structure and funtion of the membranes with which the brain is packed and of the innumerable gates, channels, receptors and pumps which they support. Fascinating evolutionary relationships are being revealed. Analysis of the cytoskeletal elements underlying axoplasmic flow, isolation of novel transmitter substances and receptors, insights into the molecular structure and functioning of synapses allow deeper understanding not only of the flow of impulses in the brain but also of such holistic phenomena as development and memory. Elements of Molecular Neurobiology reviews this new knowledge and shows how it points towards a profound theory of the brain in health and disease. While retaining the overall structure of the first edition, this updated second edition incorporates:
– Sections on new techniques, including PCR and knock-out genetics.
– New insights into the inter-relationships of neurophysiology, genes and genetic switches.
– Greatly expanded treatment of the molecular biology of metabotropic and ionotropic receptors and of voltage gated channels.
– Sustained reference to the evolutionary dimension and a new chapter on the evolutionary genetics of early brain development.
– Greater emphasis throughout on the molecular bases of neurological disease.
– New boxes containing supplementary material as diverse as retinitis pigmentosa and the discovery of synapses by Cajal and Sherrington.
– Two new appendices and over a hundred new and revised illustrations.