Fundamentals of clinical pharmacokinetics – John G. Wagner


1 op voorraad

Artikelnummer: 0914678204-M-01-A-03-13 Categorieën: ,


ISBN/EAN: 0914678204
Auteur(s): John G. Wagner
Genre: Studie en Wetenschap
Uitgave: hardcover, Engelstalig
Aantal bladzijden: 461
Uitgever: Drug Intelligence Publications Inc. Hamilton
1e Druk, Jaartal: 1975
Afmetingen: 260 x 179 x 39 mm
Gewicht: 1108 g + 130 g (verpakking) = 1238 g
Loc: M-01-A-03-13

Fundamentals of clinical pharmacokinetics – John G. Wagner

The intent of this book is to organize much of the knowledge of pharmacokinetics, with particular emphasis on human data, so that it may ultimately be useful in the clinical use of drugs. Obviously, the knowledge is also applicable to pharmacokinetic studies in animals as well as man. The book is intended to be used as a textbook for fifth and sixth years university students, as well as for graduate students. It should also make an excellent reference book for scientist in many medical and pharmaceutical disciplines. The emphasis in this book is on the use of pharmacokinetic equations, rather than on the derivation of the equations. However, in chapters 4 through 7, of the needed equations are derived. In teaching graduate students the author covers the material in chapter 6 in the first part of a pharmacokinetics course. However, in teaching undergraduate pharmacy and medical students he has not found this approach successful. Undergraduates cannot see the relevance easily. For them, the author has found it more successful to give the material in chapter 1 first, then some of the integrated expressions in chapter 2, teach the stripping technique (covered in section 2.1.1), then have the students apply the knowledge to real blood level and urinary excretion data from the literature. Once the student has performed such operations, and is shown what can be done with the results, he or she sees the relevance of pharmacokinetics very quickly. The student is, then, much more eager to go forward and learn more about the subject matter. In chapter 3 he or she is shown how to make dosage regimen calculations–which is one way to use the results of the analysis. Some of the fundamentals of statistics, required by those performing pharmacokinetic calculations, are given in chapter 8. Much of this is necessary in evaluating bioavailability which is discussed in chapter 10. Relationships between drug concentration and response, and the kinetics of pharmacologie response, are covered in chapter. In chapter 11 the effect of physiological factors and disease states (pathophysiology) on pharmacokinetics is discussed. This material is not only important for the management of the individual patient, but also in the design of many pharmacokinetic studies. In chapter 12, automated pharmacokinetic analysis is introduced and some examples are given. This final chapter indicates that in the future the computer will do most, if not all, of the repetitive calculations, leaving the student or investigator free to do more thinking about the results and the design of the next study. Symbolism is not always consistent throughout the book; this was intentional in order to get the reader used to such changes, since, in general, the pharmacokinetic literature has very inconsistent symbolism.

Extra informatie

Gewicht 1238 g
Afmetingen 260 × 179 × 39 mm